Player-coach Steve Perry is set to make his return after injury during Barnstaple's National Three South West home game against Malvern.
The former Cornish All Blacks' playmaker, who switched clubs in the summer, has been out for six weeks with a knee injury.
Director of rugby Kevin Squire will not start with Perry, but intends bringing him off the bench. "We have got Newton Abbot away next Saturday and Steve is one of a number of players I am hoping to bring back against Malvern," said Squire.
Among the other players who did not feature in the Devon Cup win over Torquay last Saturday who are likely to reappear are Tom Skelding, Linford Brock, Winston James and Mark Berry.
Brixham, at home to Maidenhead, are also looking ahead to a Devon derby against Newton Abbot. Last Saturday's 45-36 loss to Exmouth in the Devon Cup was Brixham's third defeat in a row and fourth in five matches.
Brixham's fixtures list eases over the next few Saturdays before the eagerly awaited derby tussle with Newton Abbot on December 8.
Brixham's assistant coach Ian Morgan said he wants maximum points from the next two games. "To get our season back on track we need five-point wins against Maidenhead and Malvern," said Morgan.
Exmouth can go second in the table at Weston's expense if they win the meeting between the two teams at Drove Road.
"They have been second pretty well all season, but there is only a point between them and us in third so a win will put us ahead," said Exmouth's director of rugby Chris Wright.
Exmouth are in good spirits after beating Brixham in the Devon Cup last Saturday, but have some selection issues to sort out. "Mike Wilson, Nigel Berry and Dave Bargent are all waiting to get back in the pack, but the lads who came in against Brixham have made a good case for keeping shirts," said Wright.
Newton Abbot will not be taking anything for granted away to Avonmouth Old Boys despite the ten-place gap between them in the table.
"When the weather was good the likes of Exmouth and Brixham struggled to win up there – and it won't be any easier in the wind and the rain," said Newton chief Roy Henderson.
Fit-again hooker Dean Avery should get his first start in a month out, but No.8 Ben Cole is work tied and cannot travel.
National Two South side Taunton Titans, at home to Barking, will be looking to bounce back from their 30-27 loss at Bournemouth.